IMPROVING PHARMACOKINETIC-PHARMACODYNAMIC MODELING TO INVESTIGATE ANTI-INFECTIVE CHEMOTHERAPY WITH APPLICATION TO THE CURRENT GENERATION OF ANTIMALARIAL DRUGS.

Mechanism-based pharmacokinetic-pharmacodynamic (PK/PD) modelling is the standard computational technique for simulating drug treatment of infectious diseases with the potential to enhance our understanding of drug treatment outcomes, drug deployment strategies, and dosing regimens.Standard methodologies assume only a single drug is used, it acts o

The inter-cities mobility network is of great importance in understanding outbreaks, especially in Brazil, a continental-dimension country.We adopt the data from the Brazilian Ministry of Health and the terrestrial flow of people between cities from the Brazilian Institute of Geography and Statistics database in two scales: cities from Brazil, with

This article addresses the optimal design of a geothermal binary trigeneration Shooting system for simultaneous cooling, heating, and power generation.A new processing network with alternative processing pathways is proposed.The major processing sections include geofluid production, Organic Rankine Cycle (ORC) evaporation, power generation, heat re